The Curbsiders podcast

#9 That Fecal Transplant Episode

July 8, 2016 | By

Key to Health? Or Just Gross?

Ever wonder if fecal microbiota transplants (FMT) work and how they work? Well, you’re in luck because in this episode we “curbside” Gastroenterologist, Dr. Adam Ehrlich from Temple University Hospital. On the show, we cover the ins-and-outs of procuring, preparing and performing transplants as well as future directions in this burgeoning field e.g. IBD, obesity, metabolic syndrome and more.

Take Home Points:

  1. Clostridium difficile infection is the only indication for which FMT is allowed by the FDA without special authorization
  2. FMT is VERY effective in these C difficile patients compared to standard of care (approximately 90% cure vs 30%)
  3. We are just beginning to understand the role of the microbiome in human health, and I anticipate many changes in the years ahead where modifying the microbiome will be used to help treat a number of diseases.

Recommended reading…
NEJM Journal Watch for Gastroenterology – register here

Review on novel uses for fecal transplantation
Rossen NG, et al. Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review. World J Gastroenterol. 2015 May 7;21(17):5359-71. doi: 10.3748/wjg.v21.i17.5359.

Randomized controlled trial of fresh vs frozen fecal transplantation
Fresh vs Frozen Fecal Microbiota Transplant for C diff Recurrent C difficile infection. JAMA 2016

Review on mechanisms for gut microbiota on metabolic syndromes
Qian LL, et al. Effect of the Gut Microbiota on Obesity and Its Underlying Mechanisms: an Update. Biomed Environ Sci. 2015 Nov;28(11):839-47. doi: 10.3967/bes2015.117.

CME Partner


The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit and search for this episode to claim credit.

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