In this episode our guest is Master Lipidologist, Dr. Peter Howard Jones from Baylor College of Medicine and the National Lipid Association. My guest host is Dr. Paul Williams, Clinician Educator extraordinaire from Philadelphia. We explore everything you’ll ever want to know about cholesterol and lipids. Are statins still king when it comes to cholesterol lowering? Should we be rushing to use PCSK9 inhibitors? Should we throw away older drugs like fibrates? Are nonpharmacologic therapies like niacin and fish oil worthwhile? Join us for this extensive conversation.
Disclosures:
Dr. Jones is the Chief Science Officer at the National Lipid Association. He has served as a scientific advisor to Merck, Amgen and Sanofi.
Learning objectives:
Links from the Show:
Studies that used fibrates for preventions of CV events:
Helsinki Heart Study for primary prevention NEJM 1987
VA HIT Study for secondary prevention NEJM 1999
Withdrawal of statins at the end of life
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618294/
Expert Consensus on use of Non-Statin Drugs
http://www.acc.org/latest-in-cardiology/ten-points-to-remember/2016/03/30/11/58/2016-acc-expert-consensus-decision-pathway-on-the-role-of-nonstatin
National Lipid Association recommendations for patient-centered management of dyslipidemia
https://www.lipid.org/sites/default/files/Recommendations-Part-1.pdf
Recommended websites
National Lipid Association
The Heart.org (Medscape)
Journal of Clinical Lipidology
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Comments
Very helpful. If you CARE about reducing your risk of sudden death, heart attack, or stroke take the statin....I am ready to use that line. I will work with you to find a statin medication and dose that works.....I am ready to use that line also. You did not tolerate 40mg of atorvastatin so I am going to give you just 2 little milligrams of pitavastatin....going to use that one also. Good to know can/should use fibrates and niacin with statins for triglycerides over 500 to reduce risk of pancreatitis.